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Scientific articles in 2023

Scientific articles in 2023

In 2023 ADx will continue to collaborate with its research partners to provide new and groundbreaking scientific research. A list of all published articles in 2023 can be found below. Make sure to check in once and a while, this list will be updated regularly.

1. Decreased cerebrospinal fluid Aβ 38, 40, 42, and 43 levels in sporadic and hereditary cerebral amyloid angiopathy

Anna M. De Kort, H. Bea Kuiperij, Tainá M. Marques, Lieke Jäkel, Emma van den Berg, Iris Kersten, Hugo E.P. van Berckel-Smit, Marco Duering, Erik Stoops, Wilson F. Abdo, Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Kanishk Kaushik, Andrew Davock Warren, Steven M. Greenberg, Gunnar Brinkmalm, Gisela M. Terwindt, Marieke J.H. Wermer, Floris H.B.M. Schreuder, Catharina J.M. Klijn, Marcel M. Verbeek
Ann Neurol. 2023 Jan. doi: doi.org/10.1002/ana.26610

2. LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson’s Disease and Atypical Parkinsonian Syndromes

Andrea Mancini MD, Erik Stoops MSc, Leentje Demeyer BS, Giovanni Bellomo PhD, Federico Paolini Paoletti MD, Lorenzo Gaetani MD, PhD, Massimiliano Di Filippo MD, PhD, Lucilla Parnetti MD, PhD
Mov Disord. 2023 Feb. doi: doi.org/10.1002/mds.29336

3. Plasma biomarkers predict amyloid pathology in cognitively normal monozygotic twins after 10 years

Anouk den Braber, Inge M W Verberk, Jori Tomassen, Ben den Dulk, Erik Stoops, Jeffrey L Dage, Lyduine E Collij, Frederik Barkhof, Gonneke Willemsen, Michel G Nivard, Bart N M van Berckel, Philip Scheltens, Pieter Jelle Visser, Eco J C de Geus, Charlotte E Teunissen
Brain Comm. 2023 Feb. doi: doi.org/10.1093/braincomms/fcad024

4. Biological variation of plasma SNAP-25 levels in 23 healthy volunteers

Das S., Goossens J., Vanbrabant J., Herries E., Ladenson J., Lleó A., Belbin O., Vanmechelen E.
ADPD. 2023 Mar.

5. Novel SIMOA assay formats capable of measuring VAMP2 and SNAP-25 in plasma and CSF: Analytical validation aspects

Vanmechelen E., Rocker C.D., Das S., Lleó A., Belbin O., Goossens J.
ADPD. 2023 Mar.

6. Quantification of SNAP-25 and VAMP-2 in plasma and CSF from patients with early Alzheimer’s disease using two digital immunoassays

Goossens J., Rocker C.D., Das S., Alcolea D., Herries E., Ladenson J., Lleó A., Belbin O., Vanmechelen E.
ADPD. 2023 Mar.

7. A novel ELISA immunoassay for the detection of N-terminal alpha-synuclein in CSF of patients with different synucleopathies

Stoops E., Constantinides V., Francois C., Filieux M., Kapaki E., Paraskevas G
ADPD. 2023 Mar.

8. Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease

Shorena Janelidze, Divya Bali, Nicholas J Ashton, Nicolas R Barthélemy, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Yingxin He, Anna Orduña Dolado, Gallen Triana-Baltzer, Michael J Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck, Kaj Blennow, Randall J Bateman, Oskar Hansson
Brain, Volume 146, Issue 4, 2023 April doi: doi.org/10.1093/brain/awac333

9. Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease

Yanaika S. Hok‑A‑Hin , Marta del Campo, Walter A. Boiten , Erik Stoops , Melanie Vanhooren, Afina W. Lemstra, Wiesje M. van der Flier and Charlotte E. Teunissen
J Neuroinflammation 20, 107, 2023 May doi: doi.org/10.1186/s12974-023-02796-9

10. Large-scale cerebrospinal fluid proteomic analysis in Alzheimer’s disease patients reveals five molecular subtypes with distinct genetic risk profiles

Betty M Tijms, Ellen M Vromen, Olav Mjaavatten, Henne Holstege, Lianne M Reus, Sven van der Lee, Kirsten EJ Wesenhagen, Luigi Lorenzini, Lisa Vermunt, Vikram Venkatraghavan, Niccoló Tesi, Jori Tomassen, Anouk den Braber, Julie Goossens, Eugeen Vanmechelen, Frederik Barkhof, Yolande AL Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Frode Berven, Pieter Jelle Visser
medRxiv 2023 May doi: doi.org/10.1101/2023.05.10.23289793

11. Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults

Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng & Ralph N. Martins
npj Aging 2023 Sept doi: doi.org/10.1038/s41514-023-00114-4

12. Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias

Charlotte E. Teunissen, Leighann Kimble, Sherif Bayoumy, Katharina Bolsewig, Felicia Burtscher, Salomé Coppens, Shreyasee Das, Dea Gogishvili, Bárbara Fernandes Gomes, Nerea Gómez de San José, Ekaterina Mavrina, Francisco J. Meda, Pablo Mohaupt, Sára Mravinacová, Katharina Waury, Anna Lidia Wojdała, Sanne Abeln, Davide Chiasserini, Christophe Hirtz, Lorenzo Gaetani, Lisa Vermunt, Giovanni Bellomo, Steffen Halbgebauer, Sylvain Lehmann, Anna Månberg, Peter Nilsson, Markus Otto, Eugeen Vanmechelen, Inge M.W. Verberk, Eline Willemse, Henrik Zetterberg
Molecular & Cellular Proteomics 2023 Oct doi: doi.org/10.1101/2023.05.10.23289793

13. Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum

Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen
Alz Res Therapy 2023 Oct doi: doi.org/10.1186/s13195-023-01336-0