Scientific articles in 2022
In 2022 ADx will continue to collaborate with its research partners to provide new and groundbreaking scientific research. A list of all published articles in 2022 can be found below. Make sure to check in once and a while, this list will be updated regularly.
1. Plasma p-tau231, p-tau181, PET biomarkers and cognitive change in older adults
2. Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET
eBioMedicine, Volume 76, 103837. 2022 Feb 05. doi: https://doi.org/10.1016/j.ebiom.2022.103837
3. Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer’s disease
eBioMedicine, Volume 76, 103836. 2022 Feb 11. doi: https://doi.org/10.1016/j.ebiom.2022.103836
4. Plasma p-tau181/Aβ1-42 ratio predicts Aβ-PET status and correlates with CSF-p-tau181/Aβ1-42 and future cognitive decline
medRxiv, 22272320. 2022 Mar 13. doi: doi.org/10.1002/dad2.12375
5. Comparative analysis of total alpha-Synuclein (αSYN) immunoassays reveals that they do not capture the diversity of modified αSYN proteoforms
6. Phospho-specific plasma p-tau181 assay detects clinical as well as asymptomatic Alzheimer’s disease
Steffi De Meyer, Jeroen Vanbrabant, Jolien M. Schaeverbeke, Mariska Reinartz, Emma S. Luckett, Patrick Dupont, Koen Van Laere, Erik Stoops, Eugeen Vanmechelen, Koen Poesen, Rik Vandenberghe
Annals of Clinical and Translational Neurology 2022; 9(5): 734–746. 2022 May 3. doi: 10.1002/acn3.51553
7. Diagnostic value of serum versus plasma phospho-tau for Alzheimer’s disease
35545792. 10.1186/s13195-022-01011-w
8. Differential diagnostic performance of a panel of plasma biomarkers for different types of dementia
Elisabeth H. Thijssen, Inge M.W. Verberk, Jana Kindermans, Adlin Abramian, Jeroen Vanbrabant, Andrew J. Ball, Yolande Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Erik Stoops, Christophe Hirtz, Charlotte E. Teunissen
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14:e12285. 2022 May 15. doi: https://doi.org/10.1002/dad2.12285
9. A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease, Frontotemporal Dementia, and Subjective Cognitive Decline, and the Evaluation of Candidate Proteins for Immunoassay Calibration
Int. J. Mol. Sci. , 23(13), 7221; 2022 Jun 29. doi: https://doi.org/10.3390/ijms23137221
10. Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE)
11. P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
12. Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease
Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andrea L. Benedet, Thomas K. Karikari, Juan Lantero-Rodriguez, Eugeen Vanmechelen, Theresa A. Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L. Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj Blennow
Nat med. 2022 Aug 11. doi: 10.1038/s41591-022-01925-w
13. Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer’s disease
Depypere Herman,Vergallo Andrea, Lemercier Pablo, Lista Simone, Benedet Andrea, Ashton Nicholas, Cavedo Enrica, Zetterberg Henrik, Blennow Kaj, Vanmechelen Eugeen, Hampel Harald, the Neurodegeneration Precision Medicine Initiative (NPMI)
Alzheimer’s Dement. 2022 Sep 15. doi: 10.1002/alz.12759
14. Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
NPJ Parkinsons Dis. 2022 Oct 20. doi: 10.1038/s41531-022-00388-7
15. Glutamate receptor 4 as a fluid biomarker for the diagnosis of psychiatric disorders
Nerea Gómez de San José, Julie Goossens, Mhd Rami Al Shweiki, Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Karin M. Danzer, Heiko Graf, Carlos Schönfeldt-Lecuona, Olivia Belbin, Alberto Lleó, Eugeen Vanmechelen, Markus Otto
Journal of Psychiatric Research, 2022 Dec. doi: 10.1016/j.jpsychires.2022.10.010
16. Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays
Nicholas J. Ashton, Albert Puig-Pijoan, Marta Milà-Alomà, Aida Fernández-Lebrero, Greta García-Escobar, Fernándo González-Ortiz, Przemysław R. Kac, Wagner S. Brum, Andréa L. Benedet, Juan Lantero-Rodriguez, Theresa A. Day, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Gallen Triana-Baltzer, Setareh Moughadam, Hartmuth Kolb, Paula Ortiz-Romero, Thomas K. Karikari, Carolina Minguillon, Juan José Hernández Sánchez, Irene Navalpotro-Gómez, Oriol Grau-Rivera, Rosa María Manero, Víctor Puente-Periz, Rafael de la Torre, Jaume Roquer, Jeff L. Dage, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet
Alzheimer’s Dement. 2022. doi: 10.1002/alz.12841
17. Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease
Shorena Janelidze, Divya Bali, Nicholas J Ashton, Nicolas R Barthélemy, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Yingxin He, Anna Orduña Dolado, Gallen Triana-Baltzer, Michael J Pontecorvo, Henrik Zetterberg, Hartmuth Kolb, Manu Vandijck, Kaj Blennow, Randall J Bateman, Oskar Hansson
Brain. Sep 2022. doi: doi.org/10.1093/brain/awac333
18. Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring
Nicholas J. Ashton, Shorena Janelidze, Niklas Mattsson-Carlgren, Alexa Pichet Binette, Olof Strandberg, Wagner S. Brum, Thomas K. Karikari, Fernándo González-Ortiz, Guglielmo Di Molfetta, Francisco J. Meda, Erin M. Jonaitis, Rebecca Langhough Koscik, Karly Cody, Tobey J. Betthauser, Yan Li, Eugeen Vanmechelen, Sebastian Palmqvist, Erik Stomrud, Randall J. Bateman, Henrik Zetterberg, Sterling C. Johnson, Kaj Blennow & Oskar Hansson
Nat Med 2022. doi: doi.org/10.1038/s41591-022-02074-w
19. A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias
Katharina Bolsewig, Yanaika S Hok-A-Hin, Federica N Sepe, Lynn Boonkamp, Dirk Jacobs, Giovanni Bellomo, Federico Paolini Paoletti, Eugeen Vanmechelen, Charlotte E Teunissen, Lucilla Parnetti, Eline A J Willemse
J Alzheimers Dis. 2022. doi: 10.3233/JAD-220318.
20. Bioinformatics tools and data resources for assay development of fluid protein biomarkers
Katharina Waury, Eline A. J. Willemse, Eugeen Vanmechelen, Henrik Zetterberg, Charlotte E. Teunissen & Sanne Abeln
BMC. 2022. doi: 10.1186/s40364-022-00425-w
Pankaj Kumar, Jeroen Vanbrabant, Mary Encarnacion, Ali Mousavi, Ging-Yuek Robin Hsiung, Erik Stoops, Eugeen Vanmechelen, Hans Frykman
Alzheimer’s Dement. 2022 Dec 20. doi: https://doi.org/10.1002/alz.068159