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Scientific articles in 2021

By 18 January 2022January 26th, 2022No Comments

Scientific articles in 2021

In 2021, ADx NeuroSciences’ collaborators worked intensively on groundbreaking scientific research, resulting in many R&D studies and publications. An overview of all articles with ADx involvement, published in 2021, can be found below.

1. Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease.

Pratishtha Chatterjee, Steve Pedrini, Erik Stoops, Kathryn Goozee, Victor L Villemagne, Prita R Asih, Inge M W Verberk, Preeti Dave, Kevin Taddei, Hamid R Sohrabi, Henrik Zetterberg, Kaj Blennow, Charlotte E Teunissen, Hugo M Vanderstichele, Ralph N Martins.
Transl Psychiatry. 2021 Jan 11;11(1):27. doi: 10.1038/s41398-020-01137-1.

2. Plasma β-secretase1 concentrations correlate with basal forebrain atrophy and neurodegeneration in cognitively healthy individuals at risk for AD.

Andrea Vergallo, Pablo Lemercier, Enrica Cavedo, Simone Lista, Eugeen Vanmechelen, Ann De Vos, Henrik Zetterberg, Kaj Blennow, Marie-Odile Habert, Marie-Claude Potier Bruno Dubois, Stefan Teipel, Harald Hampel, INSIGHT-preAD study group, and the Alzheimer Precision Medicine Initiative (APMI).
Alzheimers Dement. 2021 Feb 1. doi: 10.1002/alz.12228.

3. Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology.

Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow.
Acta Neuropathol. 2021 Feb 14. doi: 10.1007/s00401-021-02275-6. 

4. Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation.

Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M Fagan, Chengjie Xiong, Abhay K Singh, Kevin Taddei, Samantha Gardener, Colin L Masters, Peter R Schofield, Gerhard Multhaup, Tammie L S Benzinger, John C Morris, Randall J Bateman, Steven M Greenberg, Mark A van Buche, Erik Stoops, Hugo Vanderstichele, Charlotte E Teunissen, Graeme J Hankey, Marieke J H Wermer, Hamid R Sohrabi, Ralph N Martins, The Dominantly Inherited Alzheimer Network.
Int J Mol Sci. 2021 Mar 13;22(6):2931. doi: 10.3390/ijms22062931.

5. Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods.

James D Doecke, Cindy François, Christopher J Fowler, Erik Stoops, Pierrick Bourgeat, Stephanie R Rainey-Smith, Qiao-Xin Li, Colin L Masters, Ralph N Martins, Victor L Villemagne, Steven J Collins, Hugo Marcel Vanderstichele.
Alzheimers Res Ther. 2021 Apr 16;13(1):79. doi: 10.1186/s13195-021-00812-9.

6. Cerebrospinal fluid hemoglobin levels as markers of blood contamination: relevance for α-synuclein measurement.

Silvia Paciotti, Erik Stoops, Cindy François, Giovanni Bellomo, Paolo Eusebi, Hugo Vanderstichele, Davide Chiasserini, Lucilla Parnetti.
Clin Chem Lab Med. 2021 May 6. doi: 10.1515/cclm-2020-1521.

7. Highly specific and ultrasensitive plasma test detects Abeta(1-42) and Abeta(1-40) in Alzheimer’s disease.

Elisabeth H Thijssen, Inge M W Verberk, Jeroen Vanbrabant, Anne Koelewijn, Hans Heijst, Philip Scheltens, Wiesje van der Flier, Hugo Vanderstichele, Erik Stoops, Charlotte E Teunissen.
Sci Rep. 2021 May 6;11(1):9736. doi: 10.1038/s41598-021-89004-x.

8. Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes.

Michelle M Mielke, Ryan D Frank, Jeffrey L Dage, Andreas Jeromin, Nicholas J Ashton, Kaj Blennow, Thomas K Karikari, Eugene Vanmechelen, Henrik Zetterberg, Alicia Algeciras-Schimnich, David S Knopman, Val Lowe, Guojun Bu, Prashanthi Vemuri, Jonathan Graff-Radford, Clifford R Jack Jr, Ronald C Petersen.
JAMA Neurol. 2021 Jul 26. doi: 10.1001/jamaneurol.2021.2293.

9. Cellular Prion Protein Mediates α-Synuclein Uptake, Localization, and Toxicity In Vitro and In Vivo.

Tobias Thom, Matthias Schmitz, Anna-Lisa Fischer, Angela Correia, Susana Correia, Franc Llorens, AnnaVillar Pique, Wiebke Möbius, Renato Domingues, Saima Zafar, Erik Stoops, Christopher J Silva, Andre Fische, Tiago F Outeiro, Inga Zerr.
Mov Disord. 2021 Aug 27. doi: 10.1002/mds.28774.

10. Comparing the Clinical Utility and Diagnostic Performance of Cerebrospinal Fluid P-Tau181, P-Tau217 and P-Tau231 Assays.

Antoine Leuzy, Shorena Janelidze, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Dirk Jacobs, Claudia Cicognola, Erik Stomrud, Eugeen Vanmechelen, Jeffrey L Dage, Oskar Hansson.
Neurology. 2021 Sep 7;10.1212/WNL.0000000000012727. doi: 10.1212/WNL.0000000000012727.

11. Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer’s disease.

Pratishtha Chatterjee, Steve Pedrin, Nicholas J Ashton, Michelle Tegg, Kathryn Goozee, Abhay K Singh, Thomas K Karikari, Joel Simrén, Eugeen Vanmechelen, Nicola J Armstrong, Eugene Hone, Prita R Asih, Kevin Taddei, Vincent Doré, Victor L Villemagne, Hamid R Sohrabi, Henrik Zetterberg, Colin L Masters, Kaj Blennow, Ralph N Martins.
Alzheimers Dement. 2021 Sep 8. doi: 10.1002/alz.12447.

12. Cerebrospinal fluid neurogranin in Alzheimer’s disease studies: are immunoassay results interchangeable?

Clément Aveneau, Claire Hourregue, Emmanuel Cognat, Julien Dumurgier, Hugo Vanderstichele, Eugeen Vanmechelen, Henrik Zetterberg, Jacques Hugon, Kaj Blennow, Claire Paquet, Elodie Bouaziz-Amar.
Clin Chem Lab Med. 2021 Sep 15. doi: 10.1515/cclm-2021-0505.

13. The Alzheimer’s Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau.

Oskar Hansson, Richard Batrla, Britta Brix, Maria C Carrillo, Veronika Corradini, Rebecca M Edelmayer, Rianne N Esquivel, Christina Hall, John Lawson, Nathalie Le Bastard, José Luis Molinuevo, Laura K Nisenbaum, Sandra Rutz, Salvatore J Salamone, Charlotte E Teunissen, Christopher Traynham, Robert M Umek, Hugo Vanderstichele, Manu Vandijck, Simone Wahl, Christopher J Weber, Henrik Zetterberg, Kaj Blennow.
Alzheimers Dement. 2021 Sep;17(9):1575-1582. doi: 10.1002/alz.12316. Epub 2021 Mar 31.

14. Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy.

Anna M De Kort, H Bea Kuiperij, Daniel Alcolea, Iris Kersten, Alexandra A M Versleijen, Steven M Greenberg, Erik Stoops, Floris H B M Schreuder, Catharina J M Klijn, Alberto Lleó, Jurgen A H R Claassen, Marcel M Verbeek.
Alzheimers Res Ther. 2021 Sep 24;13(1):160. doi: 10.1186/s13195-021-00899-0.

15. The global Alzheimer’s Association round robin study on plasma amyloid β methods.

Josef Pannee, Leslie M Shaw, Magdalena Korecka, Teresa Waligorska, Charlotte E Teunissen, Erik Stoops, Hugo M J Vanderstichele, Kimberley Mauroo, Inge M W Verberk, Ashvini Keshavan, Pedro Pesini, Leticia Sarasa, Maria Pascual-Lucas, Noelia Fandos, José-Antonio Allué, Erik Portelius, Ulf Andreasson, Ritsuko Yoda, Akinori Nakamura, Naoki Kaneko, Shieh-Yueh Yang, Huei-Chun Liu, Stefan Palme, Tobias Bittner, Kwasi G Mawuenyega, Vitaliy Ovod, James Bollinger, Randall J Bateman, Yan Li, Jeffrey L Dage, Erik Stomrud, Oskar Hansson, Jonathan M Schott, Kaj Blennow, Henrik Zetterberg.
Alzheimers Dement (Amst). 2021 Oct 14;13(1):e12242. doi: 10.1002/dad2.12242. eCollection 2021.

16. Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms Ptau181, P-tau217, and P-tau231.

Sherif Bayoumy, Inge M W Verberk, Ben den Dulk, Zulaiga Hussainali, Marissa Zwan, Wiesje M van der Flier, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Jeffrey L Dage, Charlotte E Teunissen.
Alzheimers Res Ther. 2021 Dec 4;13(1):198. doi: 10.1186/s13195-021-00939-9.