Scientific articles in 2024

In 2024, ADx remains committed to fostering collaborative efforts with our research partners to pioneer new and groundbreaking scientific research. Below, you’ll find a comprehensive list of all published articles from the year. Remember to check back periodically for updates, as we continue to expand our contributions to the scientific community through ongoing collaboration.

1. Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Betty M. Tijms, Ellen M. Vromen, Olav Mjaavatten, Henne Holstege, Lianne M. Reus, Sven van der Lee, Kirsten E. J. Wesenhagen, Luigi Lorenzini, Lisa Vermunt, Vikram Venkatraghavan, Niccoló Tesi, Jori Tomassen, Anouk den Braber, Julie Goossens, Eugeen Vanmechelen, Frederik Barkhof, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Charlotte E. Teunissen, Frode S. Berven & Pieter Jelle Visser
Nat Aging 2024 Jan. doi: doi.org/10.1038/s43587-023-00550-7

2. Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology

Ashton, Nicholas & Brum, Wagner & Molfetta, Guglielmo & Benedet, Andréa & Arslan, Burak & Jonaitis, Erin & Langhough, Rebecca & Cody, Karly & Wilson, Rachael & Carlsson, Cynthia & Vanmechelen, Eugeen & Montoliu-Gaya, Laia & Lantero Rodriguez, Juan & Rahmouni, Nesrine & Tissot, Cécile & Stevenson, Jenna & Servaes, Stijn & Therriault, Joseph & Pascoal, Tharick & Zetterberg, Henrik
JAMA neurology 2024 feb. doi: doi.org/10.1001/jamaneurol.2023.5319

3. The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer’s disease

Shreyasee Das, Marie-Paule E. van Engelen, Julie Goossens, Dirk Jacobs, Bram Bongers, Jay L. P. Fieldhouse, Yolande A. L. Pijnenburg, Charlotte E. Teunissen, Eugeen Vanmechelen & Inge M. W. Verberk
Alz Res Therapy 2024 Feb. doi: doi.org/10.1186/s13195-024-01409-8

4. Profiling amyloid-β peptides as biomarkers for cerebral amyloid angiopathy.

Emma van den Berg, Iris Kersten, Gunnar Brinkmalm, Kjell Johansson, Anna M. de Kort, Catharina J. M. Klijn, Floris H. B. M. Schreuder, Johan Gobom, Erik Stoops, Erik Portelius, Eleni Gkanatsiou, Henrik Zetterberg, Kaj Blennow, Hinke B. Kuiperij, Marcel M. Verbeek
Journal of Neurochemistry 2024 Feb. doi: doi.org/10.1111/jnc.16074

5. Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy

Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Anna M. de Kort, Thijs W. van Harten, Ellis S. van Etten, Erik W. van Zwet, Erik Stoops, Cindy Francois, Bea H. Kuiperij, Catharina J.M. Klijn, Floris H.B.M. Schreuder, Louise van der Weerd, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Marcel M. Verbeek, Gisela M. Terwindt & Marieke J.H. Wermer
Alz Res Therapy 2024 Apr. doi: doi.org/10.1186/s13195-024-01457-0

6. Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET

Steffi De Meyer, Jolien M Schaeverbeke, Emma S Luckett, Mariska Reinartz, Elena R Blujdea, Isabelle Cleynen, Patrick Dupont, Koen Van Laere, Jeroen Vanbrabant, Erik Stoops, Eugeen Vanmechelen, Guglielmo di Molfetta, Henrik Zetterberg, Nicholas J Ashton, Charlotte E Teunissen, Koen Poesen, Rik Vandenberghe
Brain Communications 2024 May. doi: doi.org/10.1093/braincomms/fcae162

7. Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer’s disease and a history of traumatic brain injury

Suzan van Amerongen, Shreyasee Das, Suzie Kamps, Julie Goossens, Bram Bongers, Yolande A.L. Pijnenburg, Eugeen Vanmechelen, Everard G.B. Vijverberg, Charlotte E. Teunissen, Inge M.W. Verberk
Neurobiology of Aging 2024 Jun. doi: doi.org/10.1016/j.neurobiolaging.2024.06.001

8. Cerebrospinal fluid p-tau181, 217, and 231 indefinite Creutzfeldt–Jakobdisease with and without concomitant pathologies

Andreja Emeršič, Nicholas J. Ashton, Agathe Vrillon, Juan Lantero-Rodriguez, Jernej Mlakar, Milica Gregorič Kramberger, Fernando Gonzalez-Ortiz, Przemysław R. Kac, Maciej Dulewicz, Jörg Hanrieder, Eugeen Vanmechelen, Uroš Rot, Henrik Zetterberg, Thomas K. Karikari, Saša Čučnik, Kaj Blennow
Alzheimer’s Dement 2024 Jun. doi: doi.org/10.1002/alz.13907

9. Clinical Meaningfulness in Alzheimer’s Disease Clinical Trials. A Report from the EU-US CTAD Task Force

D. Angioni, J. Cummings, C. J. Lansdall, L. Middleton, C. Sampaio, S. Gauthier, S. Cohen, R. C. Petersen, D. M. Rentz, A. M. Wessels, S. B. Hendrix, F. Jessen, M. C. Carrillo, R. S. Doody, M. Irizarry, J. S. Andrews, B. Vellas, P. Aisen, EU/US CTAD Task force, Sandrine Andrieu, Randall Bateman, Richard Batrla, Joanne Bell, Oskar Bosson, Sasha Bozeat, Dawn Brooks, Samantha Budd Haeberlein, Teresa Buracchio, Min Cho, Matthew Choung, Gavin Cook, Darrin Crisitello, Fernando Dangond, Susan de Santi, Ellen Dennehy, Shobha Dhadda, Harjeet Dhillon, Billy Dunn, Michael Egan, Fiona Elwood, Sven Eriksson, Tom Fagan, Howard Fillit, Per-Ola Freskgard, Diana Gallagher, Gopi Gangi, Carlos Granda, David Greeley, Anna-Kaija Gronblad, Harald Hampel, Paul Hawthorne, David Henley, Joe Herring, Steve Hersch, Bill Holt, Takeshi Iwatsubo, Daryl Jones, Anja Kahl, Gene Kinney, Hartmuth Kolb, Lynn Kramer, Luka Kulic, Sanjay Kumar, Lars Lannfelt, John Lawson, Valérie Legrand, Rachel Lenington, Frank Longo, Brandy Matthews, Donna Masterman, Kristina McLinden, Sarah Mikels, Michael Miller, Mark Mintun, Hans Moebius, Cecilia Monteiro, Mario Morken, Jennifer Murphy, Tomas Odergren, Gunilla Osswald, Laura Parnas, Maria-Magdalena Patru, Charlene Prazma, Rema Raman, Larisa Reyderman, Sharon Rogers, Lise Roman, Gary Romano, Mark Roskey, Ivana Rubino, Laurie Ryan, Stephen Salloway, Rachel Schindler, Lon Schneider, David Scott, John Sims, Daniel Skovronsky, Marion Soto, Reisa Sperling, Lennert Steukers, Erik Stoops, Stephen Strittmatter, Amir Tahami, Gilles Tamagnan, Gilles Tariot, Masoud Toloue, Jacques Touchon, Eugeen Vanmechelen, Len Walt, Mark Weinberg, Michael Weiner, Anne White, Iris Wiesel, David Wilson, Lisa Yarenis, Wagner Zago & Jin Zhou
J Prev Alzheimers Dis 2024 Jun. doi: doi.org/10.14283/jpad.2024.112

10. The Alzheimer’s Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study

Nicholas J. Ashton, Ashvini Keshavan, Wagner S. Brum, Ulf Andreasson, Burak Arslan, Mathias Droescher, Stefan Barghorn, Jeroen Vanbrabant, Charlotte Lambrechts, Maxime Van Loo, Erik Stoops, Shweta Iyengar, HaYeun Ji, Xiaomei Xu, Alex Forrest-Hay, Bingqing Zhang, Yuling Luo, Andreas Jeromin, Manu Vandijck, Nathalie Le Bastard, Hartmuth Kolb, Gallen Triana Baltzer, Divya Bali, Shorena Janelidze, Shieh-Yueh Yang, Catherine Demos, Daniel Romero, George Sigal, Jacob Wohlstadter, Kishore Malyavantham, Meenakshi Khare, Alexander Jethwa, Laura Stoeckl, Johan Gobom, Przemysław R. Kac, Fernando Gonzalez-Ortiz, Laia Montoliu-Gaya, Oskar Hansson, Robert A. Rissman, Maria C. Carillo, Leslie M Shaw, Kaj Blennow, Jonathan M. Schott, Henrik Zetterberg
medRxiv 2024 Aug. doi: doi.org/10.1101/2024.08.22.24312244

11. Post hoc analysis of ADAMANT, a phase2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217

Branislav Kovacech, Nicholas C. Cullen, Petr Novak, Jozef Hanes, Eva Kontsekova, Stanislav Katina,Vojtech Parrak , Michal Fresser, Jeroen Vanbrabant, Howard H. Feldman, Bengt Winblad, Erik Stoops, Eugeen Vanmechelen and Norbert Zilka
Alz Res Therapy 2024 nov. doi: doi.org/10.1186/s13195-024-01620-7

12. Analytical and clinical performance of eight Simoa® and Lumipulse® assays for automated measurement of plasma p-tau181 and p-tau217

Anna L. Wojdała, Jeroen Vanbrabant, Sherif Bayoumy, Daniel Antwi-Berko, Nathalie Le Bastard, Wiesje M. van der Flier, Andreas Jeromin, Charlotte Lambrechts, Maxime Van Loo, Manu Vandijck, Erik Stoops, Inge M. W. Verberk & Charlotte E. Teunissen

Alz Res Therapy 2024 dec. doi: doi.org/10.1186/s13195-024-01630-5

Scientific articles in 2024