Scientific articles in 2020
In 2020, ADx NeuroSciences’ collaborators have been intensively participating in groundbreaking scientific research resulting in many R&D studies and publications. An overview of all articles with ADx involvement, published in 2020, can be found below.
1. Association of brain network dynamics with plasma biomarkers in subjective memory complainers.
Chiesa PA, Houot M, Vergallo A, Cavedo E, Lista S, Potier MC, Zetterberg H, Blennow K, Vanmechelen E, De Vos A, Dubois B, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI).
Neurobiol Aging. 2020 Apr;88:83-90. doi: 10.1016/j.neurobiolaging.2019.12.017. Epub 2019 Dec 23.
2. Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays.
Candelise N, Schmitz M, Thüne K, Cramm M, Rabano A, Zafar S, Stoops E, Vanderstichele H, Villar-Pique A, Llorens F, Zerr I.
Transl Neurodegener. 2020 Jan 17;9:5. doi: 10.1186/s40035-019-0181-9. eCollection 2020.
3. The β-Secretase BACE1 in Alzheimer’s Disease.
Harald Hampel, Robert Vassar, Bart De Strooper, John Hardy, Michael Willem, Neeraj Singh, John Zhou, Riqiang Yan, Eugeen Vanmechelen, Ann De Vos, Robert Nisticò, Massimo Corbo, Bruno Pietro Imbimbo, Johannes Streffer, Iryna Voytyuk, Maarten Timmers, Amir Abbas Tahami Monfared, Michael Irizarry, Bruce Albala, Akihiko Koyama, Naoto Watanabe, Teiji Kimura, Lisa Yarenis, Simone Lista, Lynn Kramer, Andrea Vergallo.
Biol Psychiatry 2020 Feb 13. doi: 10.1016/j.biopsych.2020.02.001. PMID: 32223911.
4. A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms.
Joke Verelst, Nick Geukens, Sabiha Eddarkaoui, Dorien Vliegen, Elien De Smidt, Joëlle Rosseels, Vanessa Franssens, Sofie Molenberghs, Cindy Francois, Erik Stoops, Maria Bjerke, Sebastiaan Engelborghs, Mohamed Laghmouchi, Sofie Carmans, Luc Buée, Eugeen Vanmechelen, Joris Winderickx, Debby Thomas.
Front Mol Biosci. 2020 Mar 31;7:48. doi: 10.3389/fmolb.2020.00048. eCollection 2020.
5. CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease.
François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Hugo Vanderstichele, Eugeen Vanmechelen, Elodie Bouaziz-Amar, Kaj Blennow, Jacques Hugon, Claire Paquet
Alzheimers Res Ther. 2020 Jul 20;12(1):88. doi: 10.1186/s13195-020-00655-w.
6. First amyloid β1-42 certified reference material for re-calibrating commercial immunoassays.
Sébastien Boulo, Julia Kuhlmann, Ulf Andreasson, Britta Brix, Iswariya Venkataraman, Victor Herbst, Sandra Rutz, Ekaterina Manuilova, Manu Vandijck, Filip Dekeyser, Maria Bjerke, Josef Pannee, Jean Charoud-Got, Guy Auclair, Stéphane Mazoua, Gregor Pinski, Stefanie Trapmann, Heinz Schimmel, Hendrik Emons, Milena Quaglia, Erik Portelius, Magdalena Korecka, Leslie M Shaw, Mary Lame, Erin Chambers, Hugo Vanderstichele, Erik Stoops, Andreas Leinenbach, Tobias Bittner, Rand G Jenkins, Vesna Kostanjevecki, Piotr Lewczuk, Johan Gobom, Henrik Zetterberg, Ingrid Zegers, Kaj Blennow.
Alzheimers Dement. 2020 Aug 4. doi: 10.1002/alz.12145.
7. BACE1 and Other Alzheimer’s-Related Biomarkers in Cerebrospinal Fluid and Plasma Distinguish Alzheimer’s Disease Patients from Cognitively-Impaired Neurosyphilis Patients.
Min Zhang, Xiaomei Zhong, Haishan Shi, Eugeen Vanmechelen, Ann De Vos, Sen Liu, Ben Chen, Naikeng Mai, Qi Peng, Xinru Chen, Zhangying Wu, Le Hou, Huarong Zhou, Cong Ouyang, Weiru Zhang, Wanyuan Liang, Chunying Dai, Yuping Ning
J Alzheimers Dis. 2020 Aug 10. doi: 10.3233/JAD-200362.
8. Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology: How specific are the conformation-specific α-synuclein antibodies?
Senthil T Kumar, Somanath Jagannath, Cindy Francois, Hugo Vanderstichele, Erik Stoops, Hilal A Lashuel
Neurobiol Dis. 2020 Sep 21;105086. doi: 10.1016/j.nbd.2020.105086.
9. Combination of plasma amyloid beta (1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology.
Inge M W Verberk, Elisabeth Thijssen, Jannet Koelewijn, Kimberley Mauroo, Jeroen Vanbrabant, Arno de Wilde, Marissa D Zwan, Sander C J Verfaillie, Rik Ossenkoppele, Frederik Barkhof, Bart N M van Berckel, Philip Scheltens, Wiesje M van der Flier, Erik Stoops, Hugo M Vanderstichele, Charlotte E Teunissen.
Alzheimers Res Ther. 2020 Sep 28;12(1):118. doi: 10.1186/s13195-020-00682-7.
10. β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification.
Harald Hampel, Simone Lista, Eugeen Vanmechelen, Henrik Zetterberg, Filippo Sean Giorgi, Alessandro Galgani, Kaj Blennow, Filippo Caraci, Brati Das, Riqiang Yan, Andrea Vergallo, Alzheimer’s Precision Medicine Initiative (APMI).
Alzheimers Res Ther. 2020 Oct 16;12(1):130. doi: 10.1186/s13195-020-00686-3.
11. Comparison of ELISA- and SIMOA-based quantification of plasma Aβ ratios for early detection of cerebral amyloidosis.
Steffi De Meyer, Jolien M Schaeverbeke, Inge M W Verberk, Benjamin Gille, Maxim De Schaepdryver, Emma S Luckett, Silvy Gabel, Rose Bruffaerts, Kimberley Mauroo, Elisabeth H Thijssen, Erik Stoops, Hugo M Vanderstichele, Charlotte E Teunissen, Rik Vandenberghe, Koen Poesen.
Alzheimers Res Ther. 2020 Dec 5;12(1):162. doi: 10.1186/s13195-020-00728-w.
12. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected.
Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo, ALFA Study
EMBO Mol Med. 2020 Dec 7;12(12):e12921. doi: 10.15252/emmm.202012921. Epub 2020 Nov 10.